VACCINATION STATUS AND COVID-19 RELATED MORTALITY: A HOSPITAL BASED CROSS SECTIONAL STUDY IN ADMITTED PATIENTS IN SOUTHWESTERN UNIVERSITY MEDICAL CENTER FROM MAY 2021 - MAY 2022
Keywords:
COVID-19 vaccine, CoronaVac, mortality, SARS-CoV-2, vaccination status, PhilippinesAbstract
The effectiveness of COVID-19 vaccines observed in clinical trials may differ in real-world populations. The Philippine Department of Health launched its national COVID-19 vaccination drive on March 1, 2021, yet hospital-level evidence on vaccination status and outcomes among Filipino inpatients remains limited. To describe the demographic and clinical profiles, disease severity, and vaccination status of adult patients admitted for COVID-19, and to examine how these factors were distributed across patient outcomes. A record-based cross-sectional study was conducted at Southwestern University Medical Center, a 126-bed tertiary hospital in Cebu City. All adult patients with rT-PCR-confirmed SARS-CoV-2 infection admitted from May 1, 2021 to May 2, 2022 were included (n = 65). Data on age, sex, comorbidities, oxygen support, length of stay, final disease severity, vaccination status, and outcome (improved, died, or discharged against medical advice) were extracted and analyzed using frequencies and proportions. Most patients were aged 40–59 years (38.5%) and male (52.3%); 70.8% had comorbidities and 72.3% required oxygen on admission. Two-thirds (66.2%) were unvaccinated, 15.4% were fully vaccinated, and 4.6% were partially vaccinated. Overall, 76.9% improved and 18.5% died. Recovery was more frequent among fully vaccinated patients (90.0%) than among unvaccinated (74.4%) and partially vaccinated patients (66.7%). No deaths occurred among patients without comorbidities, patients aged 18–39 years, or those with mild or moderate disease, whereas 75.0% of critically ill patients died. Full vaccination, younger age, and absence of comorbidities were descriptively associated with more favorable outcomes among hospitalized COVID-19 patients. Because of the small sample, formal inferential testing was not possible; larger multicenter studies are needed to confirm these associations.
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